SACRAL NEUROMODULATION – A NOVEL THERAPY FOR REFRACTORY OVERACTIVE BLADDER
Mots-clés :
Overactive bladder, Sacral neuromodulation, InterstimRésumé
Overactive bladder syndrome encompasses a series of symptoms that are both bothersome for the patient and, in most cases, serious from a medical perspective. The investigations protocol ranges from basic to very complex, yet, the treatment alternatives are limited, mainly due to insufficient efficacy or poor tolerability. Sacral neuromodulation promises to do for the bladder what a peacemaker does for the cord, which is regulating normal activity and preventing abnormal behavior. Our paper reviews the current state of the art regarding the overactive bladder, focusing on neuromodulation, its principle, indications, and known limits. Data from the literature is analyzed and presented in an analytical fashion. We conclude that this is a promising treatment alternative although limited by price, difficult implantation technique, and unpredictable efficacy.
Références
(1) W.F. Stewart, J.B. van Rooyen, G.W. Cundiff, P. Abrams, A.R. Herzog, R. Corey, et al. Prevalence and burden of overactive bladder in the United States, World J Urol., 20, 6, pp. 327-36, 2003.
(2) I. Milsom, P. Abrams, L. Cardozo, R.G. Roberts, J. Thüroff, A.J. Wein, How widespread are the symptoms of an overactive bladder and how are they managed? A population-based prevalence study, BJU Int. Jun., 87, 9, pp. 760-766, 2001.
(3) R.A. Schmidt, Treatment of unstable bladder, Urology 37, 28, 1991.
(4) M.N. Kruse, H. Noto, J.R. Roppolo, et al. Pontine control of the urinary bladder and external urethral sphincter in the rat, Brain. Res. 532, 182, 1990.
(5) T.L. Griebling, The Overactive Bladder, Evaluation, and Management. Kreder & Dmochowski (Eds), Neuromodulation: Mechanism of Action, pp. 293-302. London, England: Informa United Kingdom Ltd, 2007.
(6) E.A. Tanagho, R.A. Schmidt, B.R. Orvis, Neural stimulation for control of voiding dysfunction: a preliminary report in 22 patients with serious neuropathic voiding disorders, J. Urol., 142, p. 340, 1998.
(7) M.M. Hassouna, S.W Siegel, A. Lycklama, et al.: Sacral neuromodulation in the treatment of urgency-frequency symptoms: a multicenter study on efficacy and safety. J. Urol., 163, pp. 1849-1854, 2000.
(8) J.M. Guzman-Negron, J. Pizarro-Berdichevsky, B.C. Gill, H.B. Goldman, Can lumbosacral magnetic resonance imaging be performed safely in patients with a sacral neuromodulation device? An in vivo prospective study, J. Urol., 200, 5, pp. 1088-1092, 2018.
(9) C. Comiter, InterStim® Therapy, Theory of Mechanism of Action. Medtronic; Alleviating Pain-Restoring Health-Extending Life, Booklet 1-4, 2005.
(10) W.E. Whitehead, L. Borrud, P.S. Goode, et al. Pelvic floor disorders network. Fecal incontinence in US adults: epidemiology and risk factors, Gastroenterology, 137, pp. 512-517, 2009.
(11) Medtronic-sponsored research. Single-stage implant clinical trial, InterStim Therapy Clinical Summary Insert, 2006.
(12) Marcelissen et al., Long-term results of SNM with the tined lead procedure, J. Urol., 184, 5, pp. 1997-2000, 2010.
(13) A.C. van Voskuilen, D.J. Oerlemans, E.H. Weil, U. van den Hombergh, P.E. van Kerrebroeck, Medium-term experience of sacral neuromodulation by tined lead implantation, BJU Int. 2007 Jan, 99, 1, pp. 107-210, Epub. 2006, Sep. 6.
(14) D. Signorello, C.C. Seitz, L. Berner, E. Trenti, T. Martini, A. Galantini, L. Lusardi, M. Lodde, A. Pycha, Impact of sacral neuromodulation on female sexual function and his correlation with clinical outcome and quality of life indexes: A monocentric experience, J. Sex. Med., 8, pp. 1147-1155, 2011.
(15) G. Lombardi, N. Mondaini, G. Giubilei, A. Macchiarella, F. Cecconi, G. Del Popolo, Sacral neuromodulation for lower urinary tract dysfunction and impact on erectile function, J, Sex, Med., 5, 9, pp. 2135-40, 2008.
(16) F.N. Burks, A.C. Diokno, M.J. Lajiness, I.A. Ibrahim, K.M. Peters, Sacral neuromodulation reprogramming: is it an office burden? Int, Urogynecol J, Pelvic Floor Dysfunct., 19, 8, pp. 1137-40, 2008.
(17) S. Kaufmann, C.M. Naumann, M.F. Hamann, C. Seif, P.M. Braun, K.P. Jünemann, C. van der Horst, Unilateral vs bilateral sacral neuromodulation in pigs with formalin-induced detrusor hyperactivity, BJU Int., 103, 2, pp. 260-263, 2009, Epub 2008.
(18) P.A. Wallace, F.L. Lane, K.L. Noblett. Sacral nerve neuromodulation in patients with underlying neurologic disease, American J. of Obstetrics and Gynecology, 197, 1, pp. 96.e1-96.e5, 2007.
